RAPID COMMUNICATION Stimulation of Human Prolactin Secretion by Sulpiride

Recent studies have demonstrated that psychotropic drugs such as reserpine and chlorpromazine cause a significant increase in plasma human prolactin (hPRL) levels, frequently inducing galactorrhea (Frantz et al., 1972). Chlorpromazine is now commonly used as a means of stimulating hPRL secretion in man (Friesen et al., 1972; Turkington, 1972). Borenstein et al. (1968) first reported that galactorrhea occurred following sulpiride administration in patients with metal disorders. Sulpiride, a new type of tranquilizer, differs from phenothizine derivatives (Laville and Margarit, 1968) and has a beneficial effect on peptic ulcers (Cornet and Grivaux, 1968). This paper describes our studies on the effect of sulpiride on plasma hPRL concentrations in man. Materials and Methods